Hydrochloric Acid → HCID 44198099, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 4-{2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid ethyl ester (intermediate d) in 25 ml dioxan, 25 ml water and 0.57 g (13.6 mmol) lithium hydroxide monohydrate were added. The solution was stirred for 2 h at 100° C. After cooling to room temperature, 16 ml 1M aqueous hydrochloric acid were added upon stirring. The suspension was filtered, the filter cake washed with water and dried under high vacuum to give 2.46 g (99%) of the desired compound as colorless solid.

Provenance & Evidence