[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester → HCID 68645792, compound

HRID 1161327Notes

Reaction equation

HRID 1161327 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[C:14]([OH:16])=[O:15])[C:11]3[CH:23]=[C:24](F)[C:25](F)=[CH:26][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.C(OC(=O)C(N1C2C=CC=CC=2N=C1C1C=CC(Cl)=CC=1)C1CCCCC1)C>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[C:14]([OH:16])=[O:15])[C:11]3[CH:23]=[CH:24][CH:25]=[CH:26][C:10]=3[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 66619211[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl esterHCID 66619321[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid

Product 1

HCID 68645792HCID 68645792, compoundYield 99%

Procedure

This compound was synthesized in analogy to example 22, intermediate c, from [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester to give the desired compound as a colorless solid (99%).

Sources & evidence

ORD record
ord-f26142cbda704afa829ae739ba3508e5
Source dataset
uspto-grants-2010_10
Patent number
US07816540B2

Reaction notes

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