HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-amino-3-(trifluoromethoxy)benzoate → 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-trifluoromethoxy-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-amino-3-(trifluoromethoxy)benzoate | HCID 53419671 | — |
| Reactant | 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid ethyl ester | HCID 68645493 | — |
| Reactant | HCID 178523387 | HCID 178523387 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-trifluoromethoxy-benzoic acid methyl ester | HCID 86632024 | 85% |
Reaction Steps
This compound was synthesized in analogy to example 22, intermediate d, from [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid (example 22, intermediate c), 4-amino-3-trifluoromethoxy-benzoic acid methyl ester and using pyridine as a base to afford the title compound as a colorless solid (85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816540B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-8316967c76e74429887260d5ac1cb0ff |
| Source note | uspto-grants-2010_10 |