HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid → 1-(4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid | HCID 66619321 | — |
| Reactant | 1-(4-Amino-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester | HCID 67131121 | — |
| Reactant | 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid ethyl ester | HCID 68645493 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 1-(4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester | HCID 68645482 | — |
Reaction Steps
This compound was prepared in analogy to example 22, intermediate d, from [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid, 1-(4-amino-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester and using 4-(dimethylamino)pyridine as base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816540B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-08d042bac46b43e1a66ae155655a6315 |
| Source note | uspto-grants-2010_10 |