HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Amino-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester → 1-(4-{2-[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Amino-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester | HCID 67131121 | — |
| Reactant | 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid ethyl ester | HCID 68645493 | — |
| Reactant | [2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid | HCID 68645792 | — |
| Product | 1-(4-{2-[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester | HCID 68645569 | — |
Reaction Steps
The title compound was prepared in analogy to example 22, intermediate d), from [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid (Ex. 39/40, int. b) and 1-(4-amino-3-fluoro-phenoxy)-cyclopropanecarboxylic acid methyl ester to give the product as a light yellow foam (21%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816540B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-5a41b83690514ac8a2ab460bb170c609 |
| Source note | uspto-grants-2010_10 |