4-Amino-3-chlorobenzonitrile → HCID 68645285, compound

HRID 1161358Notes

Reaction equation

HRID 1161358 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[C:14]([OH:16])=O)[C:11]3[CH:23]=[C:24]([F:28])[C:25]([F:27])=[CH:26][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.[NH2:29][C:30]1[CH:37]=[CH:36][C:33]([C:34]#[N:35])=[CH:32][C:31]=1[Cl:38]>>[Cl:38][C:31]1[CH:32]=[C:33]([C:34]#[N:35])[CH:36]=[CH:37][C:30]=1[NH:29][C:14](=[O:16])[CH:13]([N:12]1[C:11]2[CH:23]=[C:24]([F:28])[C:25]([F:27])=[CH:26][C:10]=2[N:9]=[C:8]1[C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 5198964-Amino-3-chlorobenzonitrileHCID 66619321[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid

Product 1

HCID 68645285HCID 68645285, compoundYield 62%

Procedure

The title compound was prepared in analogy to example 22, int. d) from [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid and 4-amino-3-chlorobenzonitrile to give the desired compound as a white solid (62%). MS (ES+): M−H: 539.2.

Workup

  1. customThe title compound was prepared in analogy to example 22, int

Sources & evidence

ORD record
ord-4aab5117dd2d42be8a49677233141352
Source dataset
uspto-grants-2010_10
Patent number
US07816540B2

Reaction notes

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