4-Amino-3-(trifluoromethyl)benzonitrile → 2-[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-N-(4-cyano-2-trifluoromethyl-phenyl)-2-cyclohexyl-acetamide

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Reaction Steps

The title compound was prepared in analogy to example 22, int. d) from [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid and 4-amino-3-trifluoromethylbenzonitrile. The compound was purified by preparative HPLC using a Gemini column and a gradient of acetonitrile:water (containing 0.5% formic acid). Light brown foam (42%). MS (ES+): M+H: 537.3.

Provenance & Evidence