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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161487Generated: October 27, 2026

2-Hydrazinyl-3-methylpyridine → 4-({[3-ethoxy-4-(2-methoxyethoxy)phenyl]-[1-(3-methyl-pyridin-2-yl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]methyl}amino)benzamidine acetate

https://huagongshe.com/reaction/1161487

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Hydrazinyl-3-methylpyridineHCID 250843—
Reactant2-HydrazinylpyrimidineHCID 346558—
Reactant[2-(8-methoxy-4H-benzo[1,3]dioxin-6-yl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl esterHCID 72312724—
Reactant{2-(3-Ethoxy-4-(2-methoxyethoxy)phenyl]-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl esterHCID 72312845—
Product4-({[3-ethoxy-4-(2-methoxyethoxy)phenyl]-[1-(3-methyl-pyridin-2-yl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]methyl}amino)benzamidine acetateHCID 136366475—

Reaction Steps

The same procedure was carried out as in Examples (21i)-(21j), except that {2-(3-ethoxy-4-(2-methoxyethoxy)phenyl]-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester and (3-methylpyridin-2-yl)hydrazine were used instead of respectively the {2-(8-methoxy-4H-benzo[1,3]dioxin-6-yl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester in Example (21i) and 2-hydrazinopyrimidine in Example (21i), to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07816522B2
Source datasetuspto-grants-2010_10
ORD IDord-4ec6766f173e40adbc8afba06e660013
Source noteuspto-grants-2010_10