7-Chloro-benzo[1,4]dioxin-2-one → 2-(4-Chloro-2-hydroxy-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

関与物質

役割	名称	HCID	仕込み量
反応物	7-Chloro-benzo[1,4]dioxin-2-one	HCID 3255318	—
反応物	(2R,5S)-1-(4-fluorobenzyl)-2,5-dimethylpiperazine	HCID 23405839	—
溶媒	Toluene	HCID 1140	—
生成物	2-(4-Chloro-2-hydroxy-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone	HCID 53788724	63.3%

反応条件

温度	95 °C

反応手順

To a solution of 7-chloro-benzo[1,4]dioxin-2-one (0.48 g, 2.6 mmol) in toluene (5 mL) was added 1-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazine (0.59 g, 2.6 mmol). The resulting mixture was heated to 95° C. overnight. The reaction was cooled to ambient temperature and concentrated in vacuo. Chromatography on silica gel gave the title compound (0.67 g).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07098212B2
出典データセット	uspto-grants-2006_08
ORD ID	ord-3fa15cbc844647a681a1b88e23376cc0
出典メモ	uspto-grants-2006_08