HRID1161538

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID104169

Benzoic acid, 2-hydrazino-, monohydrochloride

C7H9ClN2O2

HCID346558

2-hydrazinopyrimidine

C4H6N4

结构：COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)cc(OCCF)c1F

HCID72312758

未命名化合物

结构：COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)c(OCCO[Si](C)(C)C(C)(C)C)cc1F

HCID72312764

未命名化合物

PRODUCTS

生成物

结构：COc1cc([C@H](Nc2ccc(C(=N)N)cc2)c2nn(-c3ccccc3C(=O)O)c(=O)[nH]2)c(F)cc1OCCO

HCID136389276

未命名化合物

PROCEDURE

实验过程

The same procedure was carried out as in Examples (3f)-(3h), except that (2-{4-[2-(t-butyldimethylsilanyloxy)ethoxy]-2-fluoro-5-methoxyphenyl}-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene)carbamic acid methyl ester and 2-hydrazinobenzoic acid hydrochloride were used instead of respectively the {2-[2-fluoro-3-(2-fluoroethoxy)-5-methoxyphenyl]-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester in Example (3f) and 2-hydrazinopyrimidine in Example (3f), to give the title compound as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6eb69b2c07654a0eb02d9c402c4833e5
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07816522B2
来源说明: uspto-grants-2010_10

反应 SMILES

CO[C:3](=[O:42])[N:4]=[C:5](SC)[C:6]([C:20]1[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH2:29][CH2:30][O:31][Si](C(C)(C)C)(C)C)=[CH:22][C:21]=1[F:39])=[N:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:18]=C(C)O[N:15]=2)=[CH:10][CH:9]=1.Cl.[NH:44]([C:46]1[CH:54]=[CH:53][CH:52]=[CH:51][C:47]=1[C:48]([OH:50])=[O:49])[NH2:45].COC(=O)N=C(SC)C(C1C=C(OC)C=C(OCCF)C=1F)=NC1C=CC(C2N=C(C)ON=2)=CC=1.N(C1N=CC=CN=1)N>>[C:14]([C:11]1[CH:10]=[CH:9][C:8]([NH:7][C@@H:6]([C:20]2[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH2:29][CH2:30][OH:31])=[CH:22][C:21]=2[F:39])[C:5]2[NH:4][C:3](=[O:42])[N:44]([C:46]3[CH:54]=[CH:53][CH:52]=[CH:51][C:47]=3[C:48]([OH:50])=[O:49])[N:45]=2)=[CH:13][CH:12]=1)(=[NH:18])[NH2:15]