4-[({3-[2-(t-butyldimethylsilanyloxy)ethoxy]-2-fluoro-5-methoxyphenyl}-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl)amino]benzonitrile → 4-({[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzonitrile

Participants

Reaction Conditions

Reaction Steps

After dissolving 3.4 g of 4-[({3-[2-(t-butyldimethylsilanyloxy)ethoxy]-2-fluoro-5-methoxyphenyl}-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl)amino]benzonitrile in 100 ml of acetic acid, 5 ml of water was added and the mixture was stirred overnight at 50° C. The reaction mixture was concentrated, and the residue was purified by NAM silica gel column chromatography (methanol-ethyl acetate) to give the title compound (2.25 g) as a light yellow solid.

Provenance & Evidence