2-Fluoro-4,5-dimethoxybenzaldehyde → {2-[2-Fluoro-5-methoxy-3-(2-methoxyethoxy)phenyl]-1-methylsulfanyl-2-[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)phenylimino]ethylidene}carbamic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoro-4,5-dimethoxybenzaldehyde	HCID 603595	—
Reactant	4-(5-Methyl-1,2,4-oxadiazol-3-yl)aniline	HCID 18188176	—
Reactant	4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)aniline	HCID 43525144	—
Reactant	2-Fluoro-5-methoxy-3-(2-methoxyethoxy)benzaldehyde	HCID 59517032	—
Reactant	[2-(2-Fluoro-4,5-dimethoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl ester	HCID 72312823	—
Product	{2-[2-Fluoro-5-methoxy-3-(2-methoxyethoxy)phenyl]-1-methylsulfanyl-2-[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)phenylimino]ethylidene}carbamic acid methyl ester	HCID 72312810	—

Reaction Steps

The same procedure was carried out as in Examples (1a) to (1d), except that 4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)phenylamine (Example (188a)) and 2-fluoro-5-methoxy-3-(2-methoxyethoxy)benzaldehyde were used instead of respectively the 4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamine and 2-fluoro-4,5-dimethoxybenzaldehyde in Example (1a), to give the title compound as a light yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07816522B2
Source dataset	uspto-grants-2010_10
ORD ID	ord-6753578ff1c346a6896dcff26f684a26
Source note	uspto-grants-2010_10