{2-(3-Hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester → 4-({[1-(3-Aminopyridin-2-yl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-[3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}amino)benzamidine acetate

HRID 1161571Notes

Reaction equation

HRID 1161571 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].[NH2:5][C:6]1[C:7]([N:12]2[C:16](=[O:17])[NH:15][C:14]([CH:18]([NH:32][C:33]3[CH:41]=[CH:40][C:36]([C:37]([NH2:39])=[NH:38])=[CH:35][CH:34]=3)[C:19]3[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH2:28][CH2:29][OH:30])[C:20]=3F)=[N:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1.COC(=O)N=C(SC)C(C1C=C(OC)C=C(O)C=1)=NC1C=CC(C2N=C(C)ON=2)=CC=1>>[C:1]([OH:4])(=[O:3])[CH3:2].[NH2:5][C:6]1[C:7]([N:12]2[C:16](=[O:17])[NH:15][C:14]([CH:18]([NH:32][C:33]3[CH:34]=[CH:35][C:36]([C:37]([NH2:39])=[NH:38])=[CH:40][CH:41]=3)[C:19]3[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH2:28][CH2:29][OH:30])[CH:20]=3)=[N:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 72312820{2-(3-Hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl esterHCID 1363892814-({[1-(3-Aminopyridin-2-yl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}amino)benzamidine acetate

Product 1

HCID 1363892844-({[1-(3-Aminopyridin-2-yl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-[3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}amino)benzamidine acetate

Procedure

The same procedure was carried out as in Examples (200a) to (200c), except that {2-(3-hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester (Example (4c)) was used instead of [2-(2-fluoro-3-hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl ester in Example (200a), to give the title compound.

Sources & evidence

ORD record
ord-c8ca4a91012b41c29dc0af503a637ad5
Source dataset
uspto-grants-2010_10
Patent number
US07816522B2

Reaction notes

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