4-Hydrazinothiazole-5-carboxylic acid methyl ester → 6-{3-[(4-Carbamimidoylphenylamino)-(2-fluoro-3,5-dimethoxyphenyl)methyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}pyridine-2-carboxylic acid trifluoroacetate

Participants

Reaction Steps

The same procedure was carried out as in Examples (180a) to (180b), except that [2-(2-fluoro-4,5-dimethoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl ester and 6-hydrazinopyridine-2-carboxylic acid methyl ester hydrochloride (Example (174a)) were used instead of respectively {2-(9-methoxy-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester and 4-hydrazinothiazole-5-carboxylic acid methyl ester in Example (180a), to give the title compound as a yellow solid.

Provenance & Evidence