[2-(4-Cyanophenylimino)-2-(4-fluoro-7-methoxy-2,3-dihydrobenzofuran-5-yl)-1-methylsulfanylethylidene]carbamic acid methyl ester → (S)-3-{3-[(4-Carbamimidoylphenylamino)-(4-fluoro-7-methoxy-2,3-dihydrobenzofuran-5-yl)methyl]-5-oxo-4,5-dihydro[1,2,4]triazol-1-yl}thiophene-2-carboxylic acid

Participants

Reaction Steps

The same procedure was carried out as in Examples (168b) to (168d), except that [2-(4-cyanophenylimino)-2-(4-fluoro-7-methoxy-2,3-dihydrobenzofuran-5-yl)-1-methylsulfanylethylidene]carbamic acid methyl ester (Example (161b)) was used instead of [2-(4-cyanophenylimino)-2-(5-fluoro-8-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)-1-methylsulfanylethylidene]carbamic acid methyl ester in Example (168b), to give the first eluting enantiomer of the title compound.

Provenance & Evidence