2-Fluoro-5-methoxy-3-(2-triisopropylsilanyloxyethoxymethyl)benzaldehyde → {2-(4-Cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxymethyl)-5-methoxyphenyl]-1-methylsulfanylethylidene}carbamic acid methyl ester

HRID 1161582Notes

Reaction equation

HRID 1161582 reaction equation
[CH3:1][O:2][C:3](=[O:28])[N:4]=[C:5]([S:26][CH3:27])[C:6](=[N:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=1)[C:7]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[C:9](O)[C:8]=1[F:16].FC1C([CH2:38][O:39][CH2:40][CH2:41][O:42][Si](C(C)C)(C(C)C)C(C)C)=CC(OC)=CC=1C=O>>[CH3:1][O:2][C:3](=[O:28])[N:4]=[C:5]([S:26][CH3:27])[C:6](=[N:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]#[N:25])=[CH:22][CH:23]=1)[C:7]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[C:9]([CH2:38][O:39][CH2:40][CH2:41][OH:42])[C:8]=1[F:16]

Participants

3

Reactant 2

HCID 595172852-Fluoro-5-methoxy-3-(2-triisopropylsilanyloxyethoxymethyl)benzaldehydeHCID 72312839[2-(4-Cyanophenylimino)-2-(2-fluoro-3-hydroxy-5-methoxyphenyl)-1-methylsulfanylethylidene]carbamic acid methyl ester

Product 1

HCID 72312796{2-(4-Cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxymethyl)-5-methoxyphenyl]-1-methylsulfanylethylidene}carbamic acid methyl ester

Procedure

The same procedure was carried out as in Examples (163a) to (163b), except that 2-fluoro-5-methoxy-3-(2-triisopropylsilanyloxyethoxymethyl)benzaldehyde was used instead of 2-fluoro-5-methoxy-3-triisopropylsilanyloxybenzaldehyde in Example (163a), to give the title compound.

Sources & evidence

ORD record
ord-9ef43b33c1ea4628a6ad2af2fe420f98
Source dataset
uspto-grants-2010_10
Patent number
US07816522B2

Reaction notes

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