HCID 86617926, compound → HCID 136389293, compound

Participants

Role	Name	HCID	Charge
Reactant	HCID 86617926	HCID 86617926	—
Reactant	(S)-4-({[2-fluoro-3-(2-fluoroethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzamidine acetate	HCID 136366453	—
Product	HCID 136389293	HCID 136389293	—

Reaction Steps

The same procedure was carried out as in Examples (3e) to (3h), except that {2-{3-[(S)-2-(t-butyldimethylsilanyloxy)-1-methylethoxy]-2-fluoro-5-methoxyphenyl}-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester was used instead of [2-(2-fluoro-3-hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl ester in Example (3e), to give the first eluting enantiomer of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07816522B2
Source dataset	uspto-grants-2010_10
ORD ID	ord-a417c01a117f4acea486d3392ad84cdb
Source note	uspto-grants-2010_10