HRID1161598

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2777595

Methyl 3-Hydrazinothiophene-2-Carboxylate

C6H8N2O2S

HCID55281298

未命名化合物

结构：COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(O)c(OC)c(OC)c1

HCID72312728

未命名化合物

结构：COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)cc(O)c1F

HCID72312745

未命名化合物

PRODUCTS

生成物

结构：COc1cc([C@H](Nc2ccc(C(=N)N)cc2)c2nn(-c3ccsc3C(=O)O)c(=O)[nH]2)cc(OCCO)c1OC

HCID136389302

未命名化合物

PROCEDURE

实验过程

The same procedure was carried out as in Example 167, except that {2-(3-hydroxy-4,5-dimethoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester (Example (159a)) and 3-hydrazinothiophene-2-carboxylic acid methyl ester were used instead of respectively the [2-(2-fluoro-3-hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl ester and 4-hydrazinothiazole-5-carboxylic acid methyl ester, to give the first eluting enantiomer of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c0b38380ad444a8ebd566bdddedbe771
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07816522B2
来源说明: uspto-grants-2010_10

反应 SMILES

CO[C:3](=[O:33])[N:4]=[C:5](SC)[C:6]([C:20]1[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([OH:30])[CH:21]=1)=[N:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:18]=C(C)O[N:15]=2)=[CH:10][CH:9]=1.C[O:35][C:36]([C:38]1[S:39][CH:40]=[CH:41][C:42]=1[NH:43][NH2:44])=[O:37].COC(=O)N=C(SC)C(C1C=C(OC)C=C(O)C=1F)=NC1C=CC(C2N=[C:61]([CH3:63])[O:60]N=2)=CC=1.COC(C1SC=NC=1NN)=O>>[C:14]([C:11]1[CH:10]=[CH:9][C:8]([NH:7][C@@H:6]([C:20]2[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH2:63][CH2:61][OH:60])[CH:21]=2)[C:5]2[NH:4][C:3](=[O:33])[N:43]([C:42]3[CH:41]=[CH:40][S:39][C:38]=3[C:36]([OH:35])=[O:37])[N:44]=2)=[CH:13][CH:12]=1)(=[NH:18])[NH2:15]