HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzonitrile → (S)-3-{3-[(4-Carbamimidoyl-3-fluorophenylamino)-(5-fluoro-8-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)methyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzonitrile | HCID 13396 | — |
| Reactant | 4-Amino-2-fluorobenzonitrile | HCID 2783413 | — |
| Reactant | (S)-3-{3-[(4-carbamimidoylphenylamino)-(5-fluoro-8-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)methyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}thiophene-2-carboxylic acid | HCID 136389292 | — |
| Product | (S)-3-{3-[(4-Carbamimidoyl-3-fluorophenylamino)-(5-fluoro-8-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)methyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}thiophene-2-carboxylic acid | HCID 136389303 | — |
Reaction Steps
The same procedure was carried out as in Examples (168a) to (168d), except that 2-fluoro-4-aminobenzonitrile [CAS No. 53312-80-4] was used instead of 4-aminobenzonitrile in Example (168a), to give the first eluting enantiomer of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816522B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-e9663efd4bb04a388aa594b2018d77ef |
| Source note | uspto-grants-2010_10 |