HRID1161600

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(OC)cc(OC)c1

HCID72312837

未命名化合物

结构：COc1cc([C@H](Nc2ccc(C(=N)N)cc2)c2nn(-c3ncsc3C(=O)O)c(=O)[nH]2)cc2c1OCOC2

HCID136389305

未命名化合物

PRODUCTS

生成物

结构：COc1cc(OC)cc([C@H](Nc2ccc(C(=N)N)cc2)c2nn(-c3ncsc3C(=O)O)c(=O)[nH]2)c1

HCID136389304

未命名化合物

PROCEDURE

实验过程

The same procedure was carried out as in Examples (166a) to (166c), except that {2-(3,5-dimethoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester (Example (225a)) was used instead of [2-(8-methoxy-4H-benzo[1,3]dioxin-6-yl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl ester in Example (166a), to give the first eluting enantiomer of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ba7428e46b254e24ab3f4ad0395630d0
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07816522B2
来源说明: uspto-grants-2010_10

反应 SMILES

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C@@H:11]([C:26]2[CH:27]=[C:28]([O:36][CH3:37])[C:29]3OCOC[C:30]=3[CH:35]=2)[C:12]2[NH:16][C:15](=[O:17])[N:14]([C:18]3[N:19]=[CH:20][S:21][C:22]=3[C:23]([OH:25])=[O:24])[N:13]=2)=[CH:6][CH:5]=1)(=[NH:3])[NH2:2].[CH3:38][O:39]C(=O)N=C(SC)C(C1C=C(OC)C=C(OC)C=1)=NC1C=CC(C2N=C(C)ON=2)=CC=1>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C@@H:11]([C:26]2[CH:27]=[C:28]([O:36][CH3:37])[CH:29]=[C:30]([O:39][CH3:38])[CH:35]=2)[C:12]2[NH:16][C:15](=[O:17])[N:14]([C:18]3[N:19]=[CH:20][S:21][C:22]=3[C:23]([OH:25])=[O:24])[N:13]=2)=[CH:6][CH:5]=1)(=[NH:3])[NH2:2]