反应详情

温度

23.5 °C

To the suspension of 200 mg (1.5 mmol) of anhydrous AlCl3 in 8 ml absolute methylene chloride was added 287.4 mg (1.5 mmol) 3-quinolinecarbonyl chloride in 5 ml methylene chloride and the reaction mixture was stirred 30 min at room 22-25° C. The (N-Methyl-2-piperidinyl)methyl-1H-indole 228.3 mg (1.0 mmol) in 5 ml of methylene chloride was added by dropwise during 1.5 h and the mixture stirred 36 h. The reaction was work-up by addition of 20 ml 2M solution of sodium hydroxide and extracted by ethyl acetate (3×20 ml). The combined extract dried by sodium sulfate. After removing of solvents the rest (0.365 g) was purified by chromatography (silica gel, toluene-triethylamine, 10:1).

1. stirringthe mixture stirred 36 h
2. extractionextracted by ethyl acetate (3×20 ml)
3. extractionThe combined extract
4. dry with materialdried by sodium sulfate
5. customAfter removing of solvents the rest (0.365 g)
6. customwas purified by chromatography (silica gel, toluene-triethylamine, 10:1)