HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-Chloro-6-(1H-pyrrol-1-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| Reactant | 2-Amino-6-chlorobenzonitrile | HCID 81056 | — |
| Reactant | 4-Chloropyridine hydrochloride | HCID 81852 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Chloro-6-(1H-pyrrol-1-yl)benzonitrile | HCID 608732 | 87.8% |
Reaction Steps
A solution of 2-amino-6-chloro-benzonitrile (30 g), 2,5-dimethoxytetrahydrofuran (30 g) and 4-chloropyridine hydrochloride (17 g) in dioxane was heated to 70° C. for 2.5 h. The solvent was evaproated in vacuo. Dichloromethane was then added to the residue and the spent 4-chloropyridine hydrochloride filtered off. The dichloromethane was evaporated in vacuo to give 1-(3′chloro-2′-cyanophenyl)pyrrole (35 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820650B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-34a8eaef4f56471e8a024e60b5043647 |
| Source note | uspto-grants-2010_10 |