Dimethyl Sulfoxide → HCID 68697190, compound

Participants

Reaction Conditions

Reaction Steps

Compound 13 (290 mg, 645 μmol) was dissolved in DMSO (2 mL) in a 15 mL screw cap pressure tube, and the resultant solution was treated with DIEA (431 μL, 2.48 mmol) and 2-fluoropyride (125 mg, 1.29 mmol). The reaction vessel was sealed and stirred at 130° C. for 14 hours. The reactor contents were cooled to 25° C., poured into H2O (30 mL), and stirred for 1 hour to produce an orange, gummy residue. The H2O was decanted off and the residue purified on silica gel (40% EtOAc/Hexanes) to provide 14 as an off-white powder (143 mg, 49% yield). HPLC Rt 6.57 minutes; LC/MS (Method F) m/z 453.3 (MH+).

Provenance & Evidence