Diisopropylethylamine → HCID 86761199, compound

Participants

Reaction Steps

A solution of 13 (200 mg, 446 μmol) and DIEA (124 μL, 880 μmol) in 1,4-dioxane (2 mL) was treated with in one portion with nicotinoyl chloride hydrochloride (80 mg, 446 μmol). The mixture was stirred at room temperature for 4 hours and concentrated under reduced pressure. The resultant residue was purified on silica (3% CH3OH/CH2Cl2) to provide 15 as an off-white solid (52 mg, 20% yield). HPLC Rt 5.7 minutes; LC/MS (Method F) m/z 427 (MH+).

Provenance & Evidence