HCID 58626070, compound → HCID 58626090, compound

HRID 1161653Notes

Reaction equation

HRID 1161653 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)[N:5]=[C:4]([NH2:16])[N:3]=1.[NH2:17][C:18]1[N:22]([CH3:23])[N:21]=[C:20]([CH2:24][CH2:25][CH3:26])[C:19]=1[C:27]([NH2:29])=[O:28]>>[NH2:16][C:4]1[N:3]=[C:2]([NH:17][C:18]2[N:22]([CH3:23])[N:21]=[C:20]([CH2:24][CH2:25][CH3:26])[C:19]=2[C:27]([NH2:29])=[O:28])[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)[N:5]=1.[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([S:14][CH3:15])=[CH:12][CH:13]=2)[N:5]=[C:4]([NH2:16])[N:3]=1

Participants

4

Reactant 2

HCID 58626070HCID 58626070, compoundHCID 58626096HCID 58626096, compound

Product 2

HCID 58626090HCID 58626090, compoundHCID 58626096HCID 58626096, compound

Procedure

5-[2-Amino-6-(4-methylsulfanylphenyl)pyrimidin-4-ylamino]-1-methyl-3-propyl-1H-pyrazole-4-carboxylic acid amide was prepared by treating 4-chloro-6-(4-methylsulfanylphenyl)pyrimidin-2-ylamine with 5-amino-1-methyl-3-propyl-1H-pyrazole-4-carboxylic acid amide according to the procedure described in step (iv) of Example 1. 4-Chloro-6-(4-methylsulfanylphenyl)pyrimidin-2-ylamine was prepared according to the procedure as described in Example 1 (Steps i-iii) using 4-methylsulfanylacetophenone in place of 4-methoxyacetophenone.

Sources & evidence

ORD record
ord-d605c5e388744bbda4ca7647d37b3a15
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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