Acetic Anhydride → HCID 86231878, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 4-chloro-6-(4-ethoxy-phenyl)-pyrimidin-2-ylamine (0.4 g, 1.6 mmol) and acetic anhydride (0.98 g, 9.61 mmol) was stirred at 80° C. for 12 hours. After completion the reaction mixture was poured into cold water (50 mL) and stirred for 10 to 15 minutes at temperature in the range of 20-40° C. The mixture was extracted with dichloromethane, washed with water, dried over anhydrous sodium sulphate, and concentrated. The residue thus obtained was purified by column chromatography using ethyl acetate-petroleum ether to afford the desired compound. Yield: 71%.

Provenance & Evidence