Sodium Hydroxide → HCID 11582418, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of [2-(3-chloro-4-methoxyphenylamino)-6-(4-methoxyphenyl)pyrimidin-4-yloxy]acetic acid ethyl ester (0.15 g, 0.33 mmol) in MeOH (5 mL) was added aqueous NaOH (prepared by adding NaOH in 2 mL of water) and the mixture was stirred for 3 hours at refluxing temperature. The mixture was then cooled to temperature in the range of 20-40° C., concentrated under vacuum, diluted with water (5 mL) and washed with ethyl acetate (2 x 2 mL). The aqueous layer was neutralized with 2N HCl. The solid precipitated was filtered off and dried to give the desired compound.

Provenance & Evidence