反应详情

温度

120 °C

A mixture of compound 1-(2-chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol (3.97 g, 13.7 mmol), 3-chloro-4-methoxyaniline (2.13 g, 13.7 mmol) in butanol (30 mL) was stirred at 120° C. for 12 hours. The mixture was then cooled to temperature in the range of 20-40° C. The solid precipitated was filtered, collected, stirred in isopropanol (10 mL), filtered, and dried to give the desired compound as a white solid. Yield: 48%.

1. temperatureThe mixture was then cooled to temperature in the range of 20-40° C
2. customThe solid precipitated
3. filtrationwas filtered
4. customcollected
5. stirringstirred in isopropanol (10 mL)
6. filtrationfiltered
7. customdried