4-(Trifluoromethoxy)aniline → HCID 11538928, compound

HRID 1161667Notes

Reaction equation

HRID 1161667 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[F:20][C:21]([F:31])([F:30])[O:22][C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=1>>[N:8]1([C:6]2[CH:5]=[C:4]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:3]=[C:2]([NH:29][C:26]3[CH:27]=[CH:28][C:23]([O:22][C:21]([F:20])([F:30])[F:31])=[CH:24][CH:25]=3)[N:7]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 6008484-(Trifluoromethoxy)anilineHCID 12161266HCID 12161266, compound

Product 1

HCID 11538928HCID 11538928, compound

Procedure

A sample of (4-morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-(4-trifluoromethoxy-phenyl)-amine was prepared from 4-(2-chloro-6-phenyl-pyrimidin-4-yl)-morpholine (0.3 g, 1.04 mmol) and 4-trifluoromethoxy phenylamine (0.14 mL, 1.04 mmol) according to a procedure analogous to that described above in Example 48.

Sources & evidence

ORD record
ord-17b7fea650274214acbd4ed9f84a48ae
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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