HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161675Generated: October 30, 2026
Sodium Carbonate → 4,6-Bis(4-fluorophenyl)pyrimidin-2-amine
https://huagongshe.com/reaction/1161675
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 4-Chloro-6-(4-fluorophenyl)pyrimidin-2-amine | HCID 11218353 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4,6-Bis(4-fluorophenyl)pyrimidin-2-amine | HCID 11254574 | — |
Reaction Steps
A mixture of compound 4-fluoro phenyl boronic acid, compound 4-chloro-6-(4-fluoro-phenyl)-pyrimidin-2-ylamine, (PPh3)4Pd and sodium carbonate in dimethylformamide was stirred for 1 hour at 25 ° C. and then for 12 hours at 80 ° C. under nitrogen atmosphere followed by purification to yield the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07820654B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-263e681cd45d4f4f9e475d63bb1f23b3 |
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| Source note | uspto-grants-2010_10 |
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