Morpholine → (6-Morpholin-4-yl-2-phenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine

Participants

Reaction Steps

A mixture of compound (6-chloro-2-phenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine (39 g, 106 mmol) and morpholine (28 mL, 319 mmol) in n-butanol (400 mL) was refluxed for 24 hours under nitrogen atmosphere. Then the reaction mixture was cooled to room temperature and evaporated under reduced pressure. The crude compound was passed through the silica gel by using 20% ethylacetate in petroleum ether to afford the compound (6-morpholin-4-yl-2-phenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine (35.5 g, 80%) as off-white solid.

Provenance & Evidence