4-amino-N-methylbenzene-1-sulfonamide → 4-(2,6-diphenyl-pyrimidin-4-ylamino)-N-methyl-benzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-2,6-diphenyl-pyrimidine (0.2 g, 0.75 mmol) in n-BuOH (7 mL) was added 4-amino-N-methyl-benzenesulfonamide (0.146 g, 0.78 mmol) and the mixture was stirred at reflux temperature for 72 hours under nitrogen. The mixture was then cooled to temperature in the range of 20-40° C., the solid precipitated was filtered off and dried to give the title compound (0.13 g, 43% yield).

Provenance & Evidence