Potassium Hydroxide → HCID 58626104, compound

HRID 1161694Notes

Reaction equation

HRID 1161694 reaction equation
C([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][C:12]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:15]=[C:14]([NH2:24])[N:13]=1)C.[OH-].[K+]>CO>[NH2:24][C:14]1[N:13]=[C:12]([NH:11][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:4]([OH:25])=[O:3])[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:15]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 58626159HCID 58626159, compound

Product 1

HCID 58626104HCID 58626104, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(2-Amino-6-phenyl-pyrimidin-4-ylamino)-benzoic acid was prepared by hydrolyzing 2-(2-amino-6-phenyl-pyrimidin-4-ylamino)-benzoic acid ethyl ester (0.2 g, 0.59 mmol) in methanol (5 mL) using aqueous solution of potassium hydroxide (6 N KOH). The mixture was concentrated under vacuum, diluted with water (5 mL), neutralized with cold 2N HCl. The solid precipitated was filtered and dried to give the desired product.

Workup

  1. concentrationThe mixture was concentrated under vacuum
  2. additiondiluted with water (5 mL)
  3. customThe solid precipitated
  4. filtrationwas filtered
  5. customdried

Sources & evidence

ORD record
ord-0b3750bb752d460781f0e8527c595ba1
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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