反应详情

温度

30 °C

4-(3-Chloro-4-methoxy-phenyl)-6-pyridin-3-yl-pyrimidin-2-yl amine was prepared by treateing 1-(3-chloro-4-methoxy-phenyl)-3-pyridin-3-yl-propane-1,3-dione (0.3 g, 1.0 mmol) with guanidine carbonate (0.21 g, 1.1 mmol) in dowtherm (7 mL) at 180° C. for 30 minutes. The mixture was cooled to temperature in the range of 20-40° C. and diluted with petroleum ether (25 mL). The mixture was stirred for 1 hour. The solid was filtered and dried to give the desired product.

1. custom4-(3-Chloro-4-methoxy-phenyl)-6-pyridin-3-yl-pyrimidin-2-yl amine was prepared
2. customat 180° C.
3. customfor 30 minutes
4. filtrationThe solid was filtered
5. customdried