Carbonic acid-guanidine (1:1) → 4-(3-Chloro-4-methoxy-phenyl)-6-pyridin-3-yl-pyrimidin-2-ylamine
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10](=O)[CH2:11][C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=O)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].C(=O)(O)O.[NH2:25][C:26]([NH2:28])=[NH:27]>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)[N:27]=[C:26]([NH2:28])[N:25]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 30 °C
Procedure
4-(3-Chloro-4-methoxy-phenyl)-6-pyridin-3-yl-pyrimidin-2-yl amine was prepared by treateing 1-(3-chloro-4-methoxy-phenyl)-3-pyridin-3-yl-propane-1,3-dione (0.3 g, 1.0 mmol) with guanidine carbonate (0.21 g, 1.1 mmol) in dowtherm (7 mL) at 180° C. for 30 minutes. The mixture was cooled to temperature in the range of 20-40° C. and diluted with petroleum ether (25 mL). The mixture was stirred for 1 hour. The solid was filtered and dried to give the desired product.
Workup
- custom4-(3-Chloro-4-methoxy-phenyl)-6-pyridin-3-yl-pyrimidin-2-yl amine was prepared
- customat 180° C.
- customfor 30 minutes
- filtrationThe solid was filtered
- customdried
Sources & evidence
- ORD record
- ord-d3f05805eec14579b1988de0bf03f41e
- Source dataset
- uspto-grants-2010_10
- Patent number
- US07820654B2
Reaction notes
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