HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propan-2-one--water (1/1) → 1-[4-(4-Methanesulfonyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propan-2-one--water (1/1) | HCID 18366337 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Reactant | 1-[4-(4-Methylsulfanyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol | HCID 58626137 | — |
| Product | 1-[4-(4-Methanesulfonyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol | HCID 11669038 | — |
Reaction Steps
1-[4-(4-Methylsulfanyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol was oxidized (0.27 g, 0.69 mmol) with oxone (1.6 g, 2.76 mmol) in acetone-water (3:1) at room temperature for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820654B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-fc6be8f6bac84170a374b70910db2df4 |
| Source note | uspto-grants-2010_10 |