Sodium Carbonate → HCID 58626139, compound

Participants

Reaction Steps

(4,6-Dichloro-pyrimidin-2-yl)-(4-trifluoromethoxy-phenyl)-amine (0.3 g, 0.92 mmol) was reacted with 4-fluoro-phenyl boronic acid (0.25 g, 1.8 mmol) in presence of a catalyst Pd(OAc)2 (7 mg, 0.02 mmol) and sodium carbonate (0.78 g, 7.4 mmol) in a solvent DMF (10 mL) at 80° C. for 12 hours. Followed by work up and column purification to yield [4,6-bis-(4-fluoro-phenyl)-pyrimidin-2-yl]-(4-trifluoromethoxy-phenyl)-amine.

Provenance & Evidence