2-Benzothiazolamine, 6-(4-morpholinyl)- → HCID 24889393, compound

HRID 1161721Notes

Reaction equation

HRID 1161721 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:21]=[C:22]4[N:26]([CH:27]=3)[C:25]3[CH:28]=[CH:29][C:30]([N:32]5[CH2:37][CH2:36]N(C)[CH2:34][CH2:33]5)=[CH:31][C:24]=3[S:23]4)=[CH:16][CH:15]=2)=[O:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].N1(C2C=CC3N=C(N)SC=3C=2)CC[O:42]CC1.CN1CCN(C2C=CC3N=C(N)SC=3C=2)CC1>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[N:21]=[C:22]4[N:26]([CH:27]=3)[C:25]3[CH:28]=[CH:29][C:30]([N:32]5[CH2:33][CH2:34][O:42][CH2:36][CH2:37]5)=[CH:31][C:24]=3[S:23]4)=[CH:18][CH:19]=2)=[O:12])[CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 9371972-Benzothiazolamine, 6-(4-morpholinyl)-HCID 24889213HCID 24889213, compoundHCID 39104846HCID 39104846, compound

Product 1

HCID 24889393HCID 24889393, compound

Procedure

1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[7-(4-methyl-piperazin-1-yl)-benzo[d]imidazo[2,1-b]thiazol-2-yl]-phenyl}-urea. was prepared in a manner similar to Steps A-D, except that in Step A, 6-morpholin-4-ylbenzothiazol-2-ylamine was substituted with 6-(4-methylpiperazin-1-yl)-1,3-benzothiazol-2-amine. 1H NMR (CDCl3) δ 9.3 (br, 1H), 7.84 (d and s, 3H), 7.59 (br, 1H), 7.56 (d, 2H), 7.49 (d, 1H), 7.20 (d, 1H), 7.05 (dd, 1H), 5.86 (s, 1H), 3.250 (t, 4H), 2.62 (t, 4H), 2.38 (s, 3H), 1.36 (s, 9H). [Compound A7]

Sources & evidence

ORD record
ord-437fcc9a43834c0981f26e13c54aa94c
Source dataset
uspto-grants-2010_10
Patent number
US07820657B2

Reaction notes

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