HCID 66592683, compound → HCID 24890062, compound

HRID 1161723Notes

Reaction equation

HRID 1161723 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11](=[O:39])[NH:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[N:20]=[C:21]4[N:25]([CH:26]=3)[C:24]3[CH:27]=[CH:28][C:29]([O:31][C:32]([C@@H:34]5CCC[NH:35]5)=[O:33])=[CH:30][C:23]=3[S:22]4)=[CH:15][CH:14]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].ON1C(=O)[CH2:44][CH2:43][C:42]1=O.C(N1CCC[C@H]1C(O)=O)(OC(C)(C)C)=O>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11](=[O:39])[NH:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[N:20]=[C:21]4[N:25]([CH:26]=3)[C:24]3[CH:27]=[CH:28][C:29]([O:31][C:32](=[O:33])[C@H:34]([NH2:35])[CH:43]([CH3:44])[CH3:42])=[CH:30][C:23]=3[S:22]4)=[CH:15][CH:14]=2)[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 66592683HCID 66592683, compoundHCID 86615413HCID 86615413, compound

Product 1

HCID 24890062HCID 24890062, compound

Procedure

In a manner similar to Step A, (2S)-pyrrolidine-2-carboxylic acid 2-{4-[3-(5-tert-butyl-isoxazol-3-yl)-ureido]-phenyl}-benzo[d]imidazo[2,1-b]thiazol-7-yl ester was made using Boc-L-proline N-hydroxysuccinimide; LC-MS: ESI 545 (M+H)+. [Compound B6]

Sources & evidence

ORD record
ord-1b4e14d4752f41eca5e4d7362e67c956
Source dataset
uspto-grants-2010_10
Patent number
US07820657B2

Reaction notes

Loading…