Water → HCID 59519199, compound

HRID 1161747Notes

Reaction equation

HRID 1161747 reaction equation
C([O:3][C:4]([C:6]1[S:33][C:9]2[N:10]=[C:11]([NH2:32])[N:12]=[C:13]([C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16](S(C4C=CC=CC=4)(=O)=O)[CH:15]=3)[C:8]=2[CH:7]=1)=[O:5])C.[OH-].[K+].O>C(O)C>[NH2:32][C:11]1[N:12]=[C:13]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[S:33][C:9]=2[N:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 59519309HCID 59519309, compound

Product 1

HCID 59519199HCID 59519199, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-amino-4-(1-benzenesulfonyl-1H-indol-3-yl)-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (80 mg, 0.17 mmol) in ethanol (6 ml) was heated to 65° C., 2M potassium hydroxide added (0.25 ml, 3 equiv.) and stirred overnight. Water was added and the volatile removed in vacuo. The solution was then neutralised and freeze dried.

Workup

  1. customthe volatile removed in vacuo
  2. customfreeze dried

Sources & evidence

ORD record
ord-8622887400e34db8963dfb6efbc02599
Source dataset
uspto-grants-2010_10
Patent number
US07820658B2

Reaction notes

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