2-Aminopyridine → HCID 68648365, compound

Participants

Reaction Steps

General method for synthesis of N-pyridyl-3-methylisoxazoleacetamides: The desired aminopyridine (0.94 g, 10 mmol) was dissolved in 20 mL of THF at 0° C. and treated with DCC (2.06 g, 10 mmol), followed with a solution of 3-methyl-5-isoxazole acetic acid (1.41 g, 10 mmol) in 10 mL of THF. After stirring at rt overnight the solvent was removed in vacuo and the residue was purified by chromatography (10% MeOH/CH2Cl2), affording the desired N-pyridyl-3-methyl-5-isoxazoleacetamide.

Provenance & Evidence