HCID 178515673, compound → HCID 178515670, compound

Participants

Reaction Steps

Add palladium hydroxide to a nitrogen purged solution of 3-(4-Benzyloxy-2,6-dichloro-benzyl)-1-(4,5,6,7-tetrahydro-1H-benzoimidazol-5-yl)-pyrrolidin-2-one (4.3 g, 9.2 mmol) (Preparation 12) in 50 ml of ethyl acetate and 15 ml of methanol. Add about 22 psi of pressurized nitrogen and stir for 16 h. Filter this mixture and concentrate to afford 3-(2,6-Dichloro-4-hydroxy-benzyl)-1-(4,5,6,7-tetrahydro-1H-benzoimidazol-5-yl)-pyrrolidin-2-one as solid product (2 g). MS: m/z (M+1)=380.

Provenance & Evidence