Lithium Hydroxide → HCID 59519498, compound

Participants

Reaction Steps

To a solution of methyl 7-fluoro-6-(2-fluoro-4-iodophenylamino)-3-methylisoxazolo[4,3-b]pyridine-5-carboxylate (250 mg, 0.56 mmol) in a mixture of THF (10 ml) and H2O (5 ml) is added a solution of LiOH (67 mg, 2.8 mmol) in H2O (2.4 ml). After stirring at room temperature for 4 h, the reaction is concentrated, acidified with 1 M HCl solution, and extracted with EtOAc (2×20 ml). The organic solution is dried over MgSO4 and concentrated to give the title compound.

Provenance & Evidence