HCID 59519011, compound → HCID 59518984, compound

Participants

Reaction Steps

4-{3-[(Isopropylcarbamoylmethyl)carbamoyl]-4-nitrophenyl}-2-methylperhydro-1,4-diazepine-1-carboxylic acid tert-butyl ester (100 mg, 0.209 mmol) and 10% Pd/C (10 mg, 0.209 mmol) in MeOH (5 mL) was stirred under 4 bar H2 (g) at room temperature overnight. The mixture was filtered through a pad of celite and the solvent removed in vacuo to afford 4-{4-amino-3-[(isopropylcarbamoylmethyl)carbamoyl]phenyl}-2-methylperhydro-1,4-diazepine-1-carboxylic acid tert-butyl ester (INTERMEDIATE V.53) (94 mg, 0.210 mmol, 100%). This was used directly without purification.

Provenance & Evidence