Trifluoroacetic acid methylene chloride → HCID 86619618, compound

HRID 1161859Notes

Reaction equation

HRID 1161859 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:17])[CH:13]([Br:16])[CH2:14][CH3:15])(C)(C)C.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20].C(Cl)Cl>>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[NH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:17])[CH:13]([Br:16])[CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 59518995HCID 59518995, compound

Product 1

HCID 86619618HCID 86619618, compound

Procedure

[3-(2-Bromobutyrylamino)propyl]carbamic acid tert-butyl ester (1.41 g, 4.36 mmol) was treated with TFA:DCM (1:1 (v/v), 20 mL) and the solution stirred at room temperature for 3 h. The volatiles were removed in vacuo and crude product, isolated as the trifluoroacetic acid salt, used directly in the next stage.

Workup

  1. customThe volatiles were removed in vacuo and crude product

Sources & evidence

ORD record
ord-bbdc5d7279404dfb92c24a5242d4f3b0
Source dataset
uspto-grants-2010_10
Patent number
US07820649B2

Reaction notes

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