HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Hydroxyamine hydrochloride | HCID 443297 | — |
| Edukt | tert-Butyl 3-cyanomorpholine-4-carboxylate | HCID 21098190 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate | HCID 21098191 | — |
Reaktionsschritte
A solution of the product of Step 3 (1 eq.), hydroxylamine hydrochloride (1.4 eq.) and triethylamine (1.7 eq.) in EtOH (0.5 M) was refluxed under nitrogen for 5 hours. Mixture was concentrated and residues taken up in EtOAc and washed with water and brine. Combined organics were dried over Na2SO4 and evaporated giving the title compound as a yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07820660B2 |
| Quelldatensatz | uspto-grants-2010_10 |
| ORD ID | ord-af0a0a8b706f466ba8a96af509673b8b |
| Quellennotiz | uspto-grants-2010_10 |