Trifluoroacetic acid methylene chloride → HCID 17961816, compound

HRID 1161906Notes

Reaction equation

HRID 1161906 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:10]([O:11][C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:9]([OH:20])[N:8]=[C:7]([CH:21]2[CH2:25][CH2:24][CH2:23][N:22]2C(OC(C)(C)C)=O)[N:6]=1)=[O:4].[C:33](O)(C(F)(F)F)=O.C(Cl)Cl>>[C:12]([O:11][C:10]1[C:9](=[O:20])[N:8]([CH3:33])[C:7]([CH:21]2[CH2:25][CH2:24][CH2:23][NH:22]2)=[N:6][C:5]=1[C:3]([O:2][CH3:1])=[O:4])(=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 178499071HCID 178499071, compound

Product 1

HCID 17961816HCID 17961816, compound

Procedure

Methyl-5-(benzoyloxy)-2-[1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-6-hydroxypyrimidine-4-carboxylate was treated with TFA:CH2Cl2 (3:7) at 0° C. The solution was warmed to room temperature and the progress of the reaction was monitored by MS analysis. After 1 h the reaction was complete and the solvent was removed under reduced pressure using a rotatory evaporator. The title product was precipitated with Et2O and collected by filtration.

Workup

  1. customthe solvent was removed under reduced pressure
  2. customa rotatory evaporator
  3. customThe title product was precipitated with Et2O
  4. filtrationcollected by filtration

Sources & evidence

ORD record
ord-329adc6f3c4240d093f6e727c78ba4c5
Source dataset
uspto-grants-2010_10
Patent number
US07820660B2

Reaction notes

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