HCID 58786837, compound → HCID 58786835, compound

HRID 1161914Notes

Reaction equation

HRID 1161914 reaction equation
[C:1]([N:9]1[CH2:13][C@H:12]([O:14]CC2C=CC=CC=2)[CH2:11][C@H:10]1[C:22]1[N:23]([CH3:41])[C:24](=[O:40])[C:25]([OH:39])=[C:26]([C:28]([NH:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)=[O:29])[N:27]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CC(O)=O.[Pd]>[C:1]([N:9]1[CH2:13][C@H:12]([OH:14])[CH2:11][C@H:10]1[C:22]1[N:23]([CH3:41])[C:24](=[O:40])[C:25]([OH:39])=[C:26]([C:28]([NH:30][CH2:31][C:32]2[CH:33]=[CH:34][C:35]([F:38])=[CH:36][CH:37]=2)=[O:29])[N:27]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 58786837HCID 58786837, compound

Product 1

HCID 58786835HCID 58786835, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

The title compound of Step 2 was dissolved in AcOH and 10% Pd/C (10% weight) was added. The mixture was stirred under H2 at atmosphere overnight. Pd/C was filtered, AcOH evaporated in vacuo, and the resulting title compound was washed with methanol.

Workup

  1. filtrationPd/C was filtered
  2. customAcOH evaporated in vacuo
  3. washthe resulting title compound was washed with methanol

Sources & evidence

ORD record
ord-96980c65ebc648c08dcfc970bca10d70
Source dataset
uspto-grants-2010_10
Patent number
US07820660B2

Reaction notes

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