HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzylamine → HCID 54712022, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | 3,3-Dimethoxypropiononitrile | HCID 93731 | — |
| Reactant | HCID 17961879 | HCID 17961879 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 54712022 | HCID 54712022 | — |
Reaction Steps
Methyl 2-(2,2-dimethoxyethyl)-5-benzoyloxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate (1.0 eq.) (prepared from 3,3-dimethoxypropionitrile by procedure similar to those set forth in Examples 1 or 2) in dry MeOH was treated with 4-fluorobenzyl amine (2.5 eq.) at reflux for 2 hours. Solvent was removed in vacuo and residue triturated with Et2O to obtain the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820660B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-a3985ab9b9504d118b014d2e6433e624 |
| Source note | uspto-grants-2010_10 |