Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Phenylmethyl (2S,4R)-2-cyano-4-methoxy-1-pyrrolidinecarboxylate | HCID 23626151 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86609165 | HCID 86609165 | — |
Reaction Steps
To benzyl-(2S,4R)-2-cyano-4-methoxypyrrolidine-1-carboxylate, dissolved in ethanol (0.4 M), hydroxylamine hydrochloride (1.3 eq.) and triethylamine (1.5 eq.) were added. The mixture was stirred at 40° C. for 4 hours then at room temperature overnight. The mixture was concentrated in vacuo and the residue dissolved in ethyl acetate washed with brine, dried over Na2SO4, filtered and concentrated to give title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07820660B2 |
|---|
| Source dataset | uspto-grants-2010_10 |
|---|
| ORD ID | ord-4055fc0e09104c6ab869580f65e50008 |
|---|
| Source note | uspto-grants-2010_10 |
|---|
