HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Benzyl-(2S)-2-[amino(hydroxyimino)methyl]4,4-difluoropyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Benzyl-(2S)-2-cyano-4,4-difluoropyrrolidine-1-carboxylate | HCID 23626153 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Benzyl-(2S)-2-[amino(hydroxyimino)methyl]4,4-difluoropyrrolidine-1-carboxylate | HCID 86609167 | — |
Reaction Steps
A solution of benzyl-(2S)-2-cyano-4,4-difluoropyrrolidine-1-carboxylate, hydroxylamine hydrochloride (1.4 eq.) and triethylamine (1.7 eq.) in ethanol was refluxed under nitrogen for 5 hours. Mixture was concentrated and residues taken up in ethyl acetate and washed with water and brine. Combined organics were dried over Na2SO4 and evaporated to give title compound as a foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820660B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-146cd6ac5367439dbf0f6501a8ab1ef7 |
| Source note | uspto-grants-2010_10 |